SINUS DELIVERY OF SUSTAINED RELEASE THERAPEUTICS

摘要

The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.

主权项

1. A system comprising:
a conduit for providing access to a paranasal sinus cavity and an implant for treating sinusitis, wherein the implant comprises a therapeutic agent dispersed within a biodegradable polymer, wherein the implant is sized and configured to be at least partially placed within the conduit and is sized and configured to be delivered from the conduit to a paranasal sinus cavity, and the implant having a first solid form while in the conduit and a second solid form in a paranasal sinus cavity, and wherein the second form has at least one characteristic that substantially prevents clearance of the implant from the paranasal sinus cavity.