| 摘要 |
The invention relates to crystalline free base of palbociclib having medium specific surface area, to flake- and/or plate-like primary particles of Palbociclib and to a modified salt break procedure for the preparation thereof. The invention is also directed to pharmaceutical compositions comprising an effective amount of palbociclib and a pH modifier and to the use of said pharmaceutical compositions as medicament, in particular for the treatment of cancer. |
