LIPOSOMES CONTAINING OLIGOPEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF MULTIPLE SCLEROSIS

摘要

[0292] A composition for the treatment of multiple sclerosis comprises a first myelin basic protein (MBP) peptide linked to a first vector, the first MBP peptide consisting of the amino acid sequence: (Rl)a-Pi-R 2)b wherein P1 is an amino acid sequence having at least 85% identity to an amino acid sequence selected from the group consisting of SEQ ID NOS: 1-3; each of R1 and R2 are amino acid sequences independently consisting of from 1 to 10 amino acids; and each of a and b are independently zero or one. Compositions of immunodominant peptides of myelin basic protein are encapsulated in manosylated liposomes. In a specific embodiment, the compositions comprise myelin basic protein (BMP) peptides MBP(46-62), MBP(124-139), and MBP(147-170).