GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES
摘要
The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
申请公布号
EP2470644(B1)
申请公布日期
2016.09.21
申请号
EP20100814245
申请日期
2010.08.24
申请人
BAYLOR COLLEGE OF MEDICINE;WILSON WOLF MANUFACTURING
发明人
LEEN, ANN MARIE;ROONEY, CLIONA;GERDEMANN, ULRIKE;VERA, JUAN;WILSON, JOHN ROBERT