发明名称 |
BIODEGRADABLE LINKERS FOR MOLECULAR THERAPIES |
摘要 |
A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided. |
申请公布号 |
EP1807092(B1) |
申请公布日期 |
2016.09.07 |
申请号 |
EP20050826283 |
申请日期 |
2005.11.04 |
申请人 |
THE CHILDREN'S HOSPITAL OF PHILADELPHIA |
发明人 |
ALFERIEV, IVAN;LEVY, ROBERT, J.;FISHBEIN, ILIA |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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