发明名称 |
Chimeric lyssavirus nucleic acids and polypeptides |
摘要 |
<p>The present invention provides chimeric nucleic acids, preferably contained on an expression vector, that encode chimeric immunogenic polypeptides. The nucleic acids encode at least site III of a lyssavirus glycoprotein, which has been found to improve the immunogenicity of lyssavirus epitopes for protection from rabies. The chimeric nucleic acids and proteins can also contain antigenic determinants for epitopes other than those of lyssavirus. Thus, the invention provides chimeric nucleic acids and polypeptides that elicit a strong immune response to multiple antigens. Use of the methods of the present invention permits DNA vaccination without the need to supply multiple antigens on separate DNA molecules.</p> |
申请公布号 |
EP1721982(B1) |
申请公布日期 |
2013.04.10 |
申请号 |
EP20060112582 |
申请日期 |
2000.04.17 |
申请人 |
BOEHRINGER INGELHEIM VETMEDICA GMBH |
发明人 |
JACOB, YVES;PERRIN, PIERRE;TORDO, NOEL;BAHLOUL, CHOKRI |
分类号 |
C12N15/47;A61K35/00;A61K39/205;C07K14/145;C12N15/62 |
主分类号 |
C12N15/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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