发明名称 |
A STABILIZED VARIANT OF ACTIVIN IIB RECEPTOR |
摘要 |
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided. |
申请公布号 |
EP2370463(B1) |
申请公布日期 |
2016.08.31 |
申请号 |
EP20090761055 |
申请日期 |
2009.11.24 |
申请人 |
AMGEN INC. |
发明人 |
SUN, JEONGHOON;TAM, LEI-TING TONY;MICHAELS, MARK LEO;BOONE, THOMAS C.;DESHPANDE, ROHINI;LI, YUE-SHENG;HAN, HQ |
分类号 |
C07K14/495;C07K14/71 |
主分类号 |
C07K14/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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