| 摘要 |
The present invention relates to a method for preparing a chitosan-based matrix (4) comprising the following steps:
- a) two separate chitosan porous layers (1, 2) obtained from lyophilisation of layers of one or more solutions of chitosan are provided,
- b) the chitosan porous layers of a) are neutralized and washed,
- c) a face (1a, 2a) of each chitosan porous layer is acidified with an acid,
- d) a fiber reinforcement member (3) is provided and positioned between the two acidified faces of the two chitosan porous layers,
- e) the two chitosan porous layers and the fiber reinforcement member are let to dry to obtain a matrix having the fiber reinforcement member embedded therein. The invention also relates to an implant comprising a matrix obtained according to such a method. |
