发明名称 |
HEMOGLOBIN-HAPTOGLOBIN COMPLEXES FOR TARGETED DRUG DELIVERY |
摘要 |
Construct-complexes of a hemoglobin, a hepatocyte modifying substance bound to the hemoglobin, and a haptoglobin bound to the hemoglobin, are provided, for administration to mammalian patients. The construct-complex may be formed ex vivo, or a hemoglobin-hepatocyte modifying substance combination may be administered to the patient so that haptoglobin in the mammalian body bonds thereto to form the construct-complex in vivo. Disorders of the liver may be diagnosed and treated using construct-complexes described herein. |
申请公布号 |
EP1075280(B1) |
申请公布日期 |
2016.08.24 |
申请号 |
EP19990919005 |
申请日期 |
1999.04.30 |
申请人 |
THERAPURE BIOPHARMA INC. |
发明人 |
ADAMSON, J., GORDON;WODZINSKA, JOLANTA, MARIA;MOORE, MARIE, SYLVIE, CELINE |
分类号 |
A61K47/48;A61K38/16;A61K49/00;A61K51/08;A61P1/16;A61P43/00;C07K14/805 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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