A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
申请公布号
EP3054991(A1)
申请公布日期
2016.08.17
申请号
EP20140796327
申请日期
2014.10.10
申请人
MERSANA THERAPEUTICS, INC.
发明人
YURKOVETSKIY, ALEKSANDR V.;YIN, MAO;LOWINGER, TIMOTHY B.;THOMAS, JOSHUA D.;STEVENSON, CHERI A.;GURIJALA, VENU R.