发明名称 MODIFIED AMINO ACIDS COMPRISING TETRAZINE FUNCTIONAL GROUPS, METHODS OF PREPARATION, AND METHODS OF THEIR USE
摘要 Provided herein are modified amino acids comprising a tetrazine groups according to Formula I: polypeptides, antibodies, payloads and conjugates comprising these modified amino acid residues derived from the modified amino acids, and methods of producing the polypeptides, antibodies, payloads and conjugates comprising the modified amino acid residues. The polypeptides, antibodies, payloads and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.
申请公布号 EP3055298(A1) 申请公布日期 2016.08.17
申请号 EP20140789716 申请日期 2014.10.10
申请人 SUTRO BIOPHARMA, INC. 发明人 YANG, WENJIN;YIN, QUN
分类号 C07D401/12;A61K39/395;A61K47/48;C07D257/08;C07D409/12 主分类号 C07D401/12
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