| 摘要 |
Discloses is a method for preparign one of components of a novel antihypertensive drug of LCZ696, i.e. sacubitril (sacubitril, AHU-377, I). The method comprises the following preparation steps: carrying out the steps of cyclization, addition, debenzylation, ring opening, esterification, amidation and the like on a chiral induction reagent (S)-1-(alpha-aminobenzyl)-2-naphthol (S-betti Base) and 2R-methyl-4-oxo-butyric acid to prepare sacubitril (I). The preparation method has readily available raw materials, simple in process, is economic and environmentally friendly, and is suitable for industrial production. |
