发明名称 |
METHOD OF PREPARING IRON OXIDE NANOPARTICLES COATED WITH HYDROPHILIC MATERIAL, AND MAGNETIC RESONANCE IMAGING CONTRAST AGENT USING THE SAME |
摘要 |
The present invention relates to a method of preparing biocompatible iron oxide nanoparticles by coating iron oxide nanoparticles having improved magnetism via annealing treatment using salt particles with a hydrophilic material and to a magnetic resonance imaging (MRI) contrast agent including the iron oxide nanoparticles prepared thereby. Among hydrophilic materials, carboxymethyl dextran (CM-dextran) is the most efficient in terms of stabilizing the annealed iron oxide nanoparticles and exhibiting contrast effects. |
申请公布号 |
EP2673006(A4) |
申请公布日期 |
2016.07.20 |
申请号 |
EP20120744201 |
申请日期 |
2012.02.06 |
申请人 |
HANWHA CHEMICAL CORPORATION |
发明人 |
HYEON, TAEGHWAN;PIAO, YUANZHE;PARK, YONG IL |
分类号 |
A61K49/18;A61K9/16;A61K9/28;A61K47/30;A61K49/04 |
主分类号 |
A61K49/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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