发明名称 |
未成熟な単球性樹状細胞の活性化を誘導するための組成物および方法 |
摘要 |
The present invention provides methods for inducing the maturation of immature dendritic cells (DC) and for activating those cells without the use of a dendritic cell maturation agent. The activated DC can be used for inducing an antigen specific T cell response. Methods of the invention can also comprise the addition of a directional maturation agent, such as interferon gamma, to induce a Th-I and/or Th-2 bias in the response obtained. The present invention also provides dendritic cell populations useful for activating and for inducing antigen specific T cells. Similarly, activated antigen specific T cell populations, and methods of making the same are provided. |
申请公布号 |
JP5954918(B2) |
申请公布日期 |
2016.07.20 |
申请号 |
JP20080544561 |
申请日期 |
2006.12.08 |
申请人 |
ノースウエスト バイオセラピューティクス, インコーポレイテッド |
发明人 |
ボイントン, オールトン エル.;ボッシュ, マーニックス エル. |
分类号 |
C12N5/0784;A61K39/00;A61P31/04;A61P31/12;A61P35/00 |
主分类号 |
C12N5/0784 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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