PEGYLATED RECOMBINANT CONSENSUS INTERFERON VERSION CONJUGATE AND PREPARATION METHOD AND USE THEREOF

摘要

FIELD: chemistry.SUBSTANCE: invention relates to biotechnology, specifically to obtaining a pegylated recombinant consensus interferon version conjugate, and can be used in medicine. The invention enables to obtain an interferon-based anti-HBV drug, in which the activated PEG molecule is linked through a short linker to the α-amino group of glycine at the N-end of the recombinant consensus interferon version.EFFECT: invention enables to obtain an anti-HBV drug with high water solubility and low toxicity and immunogenicity compared to a natural interferon.3 cl, 6 dwg, 12 ex