发明名称 |
HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS |
摘要 |
Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided. |
申请公布号 |
EP3041484(A1) |
申请公布日期 |
2016.07.13 |
申请号 |
EP20140841728 |
申请日期 |
2014.09.08 |
申请人 |
ACADEMIA SINICA |
发明人 |
WONG, CHI-HUEY;YU, ALICE L.;LIN, KUN-HSIEN;WU, TAI-NA |
分类号 |
A61K35/14;A61K31/7012;A61K31/739 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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