BISPECIFIC ANTIBODY AGAINST TNF-ALPHA AND SYNOVIAL MICROVASCULATURE OF ARTHRITIS PATIENTS

摘要

The present invention provides bispecific molecule comprising: (i) a first antigen binding portion which specifically targets the synovial microvasculature of arthritis patients and which binds to the same epitope as an antigen binding polypeptide comprising the amino acid sequence shown as SEQ ID No 11; and (ii) a second antigen binding portion which binds tumour necrosis factor alpha (TNF-α). The present invention also relates to the use of such bispecific molecules in the prevention and/or treatment of arthritis.