发明名称 |
COMPOSITIONS FEATURING AN ATTENUATED NEWCASTLE DISEASE VIRUS AND METHODS OF USE FOR TREATING NEOPLASIA |
摘要 |
The present invention provides methods for inducing regression of tumors in human subjects, the methods utilize a modified mesogenic strain of Newcastle disease virus (NDV) with modified F protein cleavage site, which is non-pathogenic to poultry (lentogenic), but exhibits oncolytic properties. The disclosed methods provide safe, effective and reliable means to induce regression of a tumor in an individual in need thereof. These methods overcome the drawbacks of using pathogenic strains of viruses for human therapy. |
申请公布号 |
EP3041490(A1) |
申请公布日期 |
2016.07.13 |
申请号 |
EP20140761317 |
申请日期 |
2014.09.02 |
申请人 |
MEDIMMUNE LIMITED |
发明人 |
CHENG, XING;CARROLL, DANIELLE;MCCOURT, MATTHEW;GALINSKI, MARK;JIN, HONG |
分类号 |
A61K35/76;C07K14/535;C12N15/86 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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