发明名称 |
ENHANCING IMMUNITY TO TUBERCULOSIS |
摘要 |
The invention is directed to compositions and methods for generating or enhancing the immune system of a patient against infection by a pathogen, and in particular MTB. Compositions of the invention contain one or more non-naturally occurring antigens that generate an effective cellular or humoral immune response to MTB and/or antibodies that are specifically reactive to mycolic acid or to the surface of MTB. The greater activity of the immune system generated by a vaccine of the invention involve an conjugation of peptides to increase in the generation of memory T cells that provide for a greater and/or longer lived or extended response to an MTB infection. Preferably a response involves an increased generation of antibodies that enhance immunity against MTB infection and promote an enhanced phagocytic response. |
申请公布号 |
EP3038648(A2) |
申请公布日期 |
2016.07.06 |
申请号 |
EP20140839667 |
申请日期 |
2014.08.29 |
申请人 |
LONGHORN VACCINES AND DIAGNOSTICS, LLC |
发明人 |
FISCHER, GERALD W.;DAUM, LUKE T.;SEI, CLARA JABET |
分类号 |
C07K16/12;A61K39/04;C07K14/35 |
主分类号 |
C07K16/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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