NOVEL TRANSLOCATIONS IN LUNG CANCER

摘要

The invention relates to methods for determining the presence or absence of striatin-anaplastic lymphoma kinase (STRN-ALK) gene fusion and/or a Fibroblast Growth Factor Receptor 3—transforming acidic coiled-coil containing protein 3 (FGFR3-TACC3) gene fusion in an individual, especially an individual suffering from lung cancer. The invention further relates to a method for diagnosing an individual as having adenocarcinoma, and to a method for treating said individual. The invention additionally relates to a method for diagnosing an individual as having squamous cell carcinoma, and to a method for treating said individual.

主权项

1. A method for determining the presence or absence of striatin-anaplastic lymphoma kinase (STRN-ALK) gene fusion and/or a Fibroblast Growth Factor Receptor 3—transforming acidic coiled-coil containing protein 3 (FGFR3-TACC3) gene fusion in an individual, said method comprising:
a) evaluating a relevant nucleic acid sample of said individual to determine whether a portion of STRN nucleic acid is adjacent to a portion of ALK nucleic acid on a single polynucleotide and/or whether a portion of FGFR3 nucleic acid is adjacent to a portion of TACC3 nucleic acid on a single polynucleotide; and b) identifying said individual as having a STRN-ALK gene fusion when a portion of the STRN nucleic acid is adjacent to a portion of the ALK nucleic acid on a single polynucleotide and/or as having a FGFR3-TACC3 gene fusion when a portion of the FGFR3 nucleic acid is adjacent to a portion of the TACC3 nucleic acid on a single polynucleotide.