| 发明名称 |
ABUSE-PROOFED ORAL DOSAGE FORM |
| 摘要 |
The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N. |
| 申请公布号 |
US2016184295(A1) |
申请公布日期 |
2016.06.30 |
| 申请号 |
US201615059730 |
申请日期 |
2016.03.03 |
| 申请人 |
GRÜNENTHAL GMBH |
发明人 |
BARTHOLOMÄUS Johannes;KUGELMANN Heinrich;ARKENAU-MARIC Elisabeth |
| 分类号 |
A61K31/485;A61K9/00;A61K9/20;A61K9/28 |
主分类号 |
A61K31/485 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An abuse-proofed oral dosage form with controlled opioid release for once daily administration, comprising at least one opioid with potential for abuse (A) and/or one of the physiologically acceptable compounds thereof, polyethylene oxide having a molecular weight of 0.5 million to 15 million (C), optionally delayed release auxiliary substances, optionally physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, said abuse-proofed oral dosage form exhibiting a breaking strength of at least 500 N. |
| 地址 |
Aachen DE |
