发明名称 |
RECOMBINANT PLASMID DNA pFK4, ENSURING SYNTHESIS OF RECOMBINANT PEPTIDE RL4, WHICH IS ANALOGUE OF HUMAN KAPPA-CASEIN FRAGMENT, RECOMBINANT STRAIN OF BACTERIA ESCHERICHIA COLI XL1-BLUE/pFK4 AND RECOMBINANT PEPTIDE RL, ANALOGUE OF HUMAN KAPPA-CASEIN FRAGMENT, WHICH POSSESSES APOPTOTIC ACTIVITY WITH RESPECT TO CANCER CELLS |
摘要 |
The invention relates to recombinant plasmid DNA, which ensures increased yield of recombinant peptide RL4, containing fragment of human kappa-casein, recombinant strain of Escherichia coli (deposited at CEMTC ICBFM SB RAS under number EMTC 1347), which produces recombinant peptide RL4, analogue of human kappa-casein with increased yield, and recombinant peptide RL4, possessing increased apoptotic activity with respect to tumour cells, which consists of three components: N-terminal polyhistidine sequence MRGSHHHHHHGS, the residue of methionine, introduced into construction for possibility of cleaving polyhistidine sequence, and fragment of human kappa-casein from 49 to 122 a.r. The invention can be applied in biotechnology. |
申请公布号 |
EA023475(B1) |
申请公布日期 |
2016.06.30 |
申请号 |
EA20120001337 |
申请日期 |
2012.10.08 |
申请人 |
FEDERAL STATE BUDGET INSTITUTION OF SCIENCE INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE OF THE SIBERIAN BRANCH OF THE RUSSIAN ACADEMY OF SCIENCES (ICBFM SB RAS) |
发明人 |
POTAPENKO MIROSLAVA, OLEGOVNA;SAVELJEVA ANNA, VALENTINOVNA;FOMIN ALEXANDER, SERGEEVICH;TROSHKOVA GALINA, PAVLOVNA;KOVAL OLGA, ALEXANDROVNA;KULIGINA ELENA, VLADIMIROVNA;SEMENOV DMITRY, VLADIMIROVICH;RICHTER VLADIMIR, ALEXANDROVICH |
分类号 |
C12N15/00;C07K14/47;C12N1/21;C12N15/70 |
主分类号 |
C12N15/00 |
代理机构 |
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