REMOVAL OF MICROORGANISMS FROM CELL CULTURE MEDIA BY MICROPOROUS MEMBRANES WITH ANTIFOULING COATING

摘要

Compositions and methods are provided for removing viral contaminants from a chemically defined cell culture medium by using microporous membranes having a coating with acomposition resistant to or exhibiting reduced fouling by one or more components in a chemically defined cell culture medium. The coating comprises a copolymer formed from monomer solutions comprising diacetone acrylamide (DACm) and poly(ethylene glycol) diacrylate (PEGDA).