发明名称 |
2-MORPHOLIN-4,6-DISUBSTITUTED PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF |
摘要 |
Disclosed is a 2-morpholin-4,6-disubstituted pyrimidine derivative as shown in formula (I) below, and a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof, and a pharmaceutical composition thereof and a use thereof, wherein the definition of each group is as shown in the description. The compound has a PI3K kinase inhibition activity, and has a relatively high inhibitive ability and a low cytotoxicity against PIK3CA mutant breast cancer cell strains T47D and MCF-7. |
申请公布号 |
WO2016095833(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
WO2015CN97739 |
申请日期 |
2015.12.17 |
申请人 |
SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD;YANGTZE RIVER PHARMACEUTICAL GROUP CO.,LTD |
发明人 |
SHEN, SIDA;NI, XIAOJING;ZHANG, ZHIYUAN;YANG, ZHENG;HE, XIANGYU;WANG, WEIWEI;ZHOU, FUSHENG |
分类号 |
C07D413/14;A61K31/5377;A61P35/00;C07D239/42;C07D401/04;C07D401/14 |
主分类号 |
C07D413/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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