USE OF MARKERS IN THE DIAGNOSIS AND TREATMENT OF PROSTATE CANCER

摘要

The invention provides method for diagnosis, monitoring, and prognosis of prostate cancer using one or more of keratin 4, keratin 7, keratin 8, keratin 15, keratin 18, keratin 19, tubulin-beta 3, filamin B, and LY9, and PSA. The invention provides kits for practicing the methods of the invention.

主权项

1. A method for diagnosing an abnormal prostate state in a subject comprising:
(1) isolating a serum sample or a plasma sample from a subject having or suspected of having an abnormal prostate state and detecting the level of one or more of the prostate cancer related markers filamin B and keratin 19 in the serum sample or plasma sample; and (2) comparing the level of the one or more prostate cancer related markers in the biological sample with the level of the one or more prostate cancer related markers in a normal control sample, wherein an altered level of the one or more prostate cancer related markers in the biological sample relative to the normal control sample is indicative of an abnormal prostate state in the subject.