| 发明名称 |
INCREASING THE EXPRESSION OF A TRANSGENE IN EUKARYOTIC CELLS BY REDUCING RNA INTERFERENCE |
| 摘要 |
Described are methods for increasing the expression of a transgene in eukaryotic cells by reducing RNA interference (RNAi), and variant cells produce by the method. The methods and variant cells are useful, for example, for the efficient production of therapeutic and industrial polypeptides in eukaryotic cells. |
| 申请公布号 |
US2016177319(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201414909927 |
申请日期 |
2014.07.31 |
| 申请人 |
DANISCO US INC. |
发明人 |
MIASNIKOV Andrei |
| 分类号 |
C12N15/67;C12N9/42;C12N9/48;C12N9/30;C12N9/16;C12N9/12 |
主分类号 |
C12N15/67 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for increasing the expression level of a transgene in eukaryotic cells, comprising introducing a genetic alteration into the cells, which genetic alteration reduces the amount of RNA interference in the cells compared to the amount of RNA interference in the absence of the genetic alteration. |
| 地址 |
Palo Alto CA US |
