发明名称 |
DESIGNING A SOLUBLE FULL-LENGTH HIV-1 GP41 TRIMER |
摘要 |
Described herein is a soluble HIV-1 retrovirus transmembrane glycoprotein gp41 trimer (Soc-gp41M-Fd) containing a partial ectodomain and the cytoplasmic domain, that is fused to the small outer capsid (Soc) protein of bacteriophage T4 and the Foldon domain of the bacteriophage T4 fibritin (Fd). The gp41 trimer that has a prehairpin structure could be utilized to understand the mechanism of viral entry and as a candidate for development of HIV-1 vaccines, diagnostics and therapeutics. Other secondary embodiments of the gp41 proteins containing different modifications are also disclosed. According to one embodiment, the gp41 trimer is further attached to a cell penetration peptide (CPP). Methods of producing gp41 trimers are also disclosed. |
申请公布号 |
EP2925787(A4) |
申请公布日期 |
2016.06.22 |
申请号 |
EP20130858143 |
申请日期 |
2013.11.27 |
申请人 |
THE CATHOLIC UNIVERSITY OF AMERICA |
发明人 |
RAO, VENIGALLA B.;GAO, GUOFEN |
分类号 |
C07K14/005;C07K14/155;C07K19/00;C12N15/62 |
主分类号 |
C07K14/005 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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