发明名称 |
FABRICATION OF VASCULARIZED TISSUE USING MICROFABRICATED TWO-DIMENSIONAL MOLDS |
摘要 |
Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, wherein the first and second molds or polymer scaffolds have means defining microchannels positioned toward the semi-permeable membrane, wherein the first and second molds or polymer scaffolds are fastened together; and (b) animal cells. Methods for producing complex, three-dimensional tissues or organs from tissue lamina are also provided. |
申请公布号 |
EP1490471(B1) |
申请公布日期 |
2016.06.15 |
申请号 |
EP20030718019 |
申请日期 |
2003.03.25 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
VACANTI, JOSEPH, P.;SHIN, YOUNG-MOON, MICHAEL;OGILVIE, JENNIFER;SEVY, ALEXANDER;MAEMURA, TOMOYUKI;ISHI, OSAMU;KAAZEMPUR-MOFRAD, MOHAMMAD REZA;BORENSTEIN, JEFFREY T.;KING, KEVIN R.;WANG, CHIAO-CHUN;WEINBERG, ELI |
分类号 |
C12N5/07;A61F;A61L27/36;A61L27/38;B22C9/22;C12M1/00;C12M1/12;C12M3/00;C12M3/04;C12N5/00;C12N5/071 |
主分类号 |
C12N5/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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