| 摘要 |
An obj ect is to provide a novel production method suitable for industrial production of a 3,3-dimethyl-3,4-dihydro-1H-quinoxalin-2-one derivative and a synthetic intermediate for the method. Provided is a method for producing a compound represented by formula (1):
wherein R 1 represents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aryl group, R 2 represents a hydrogen atom, an optionally substituted alkyl group, a hydroxy group, or a nitrogen atom-protecting group, R 3 represents a hydrogen atom, an optionally substituted alkyl group, a hydroxy group, or a nitrogen atom-protecting group, and X represents a hydroxy group or a leaving group,
or a salt thereof, the method comprising the steps of:
reacting a compound represented by formula (2):
wherein R 1 , R 2 , and X are the same as defined in formula (1), R 4 represents an optionally substituted alkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aryl group,
or a salt thereof with a nitrating agent to obtain a compound represented by formula (3):
wherein R 1 , R 2 , R 4 , and X are the same as defined in formulae (1) and (2),
or a salt thereof, and
reducing the compound represented by formula (3) or the salt thereof to obtain the compound represented by formula (1) or the salt thereof. |
