发明名称 |
NEUROCALCIN DELTA INHIBITORS AND THERAPEUTIC AND NON-THERAPEUTIC USES THEREOF |
摘要 |
The present invention relates to an inhibitor of neurocalcin delta (NCALD) for use in a method for the treatment or prevention of a patient suffering from a disorder associated with a pathological calcium homeostasis. Furthermore, the present invention refers to the use of such inhibitor of NCALD for inducing axon proliferation in vitro and to a method for the differentiation and/or maturation of neuronal stem cells (NSCs) in vitro and to the use of such inhibitor of NCALD to restore impaired endocytosis being a consequence of disturbed Ca2+ homeostasis in synaptic terminals essential for development, maturation and maintenance of synapses and neuromuscular junctions (NMJs). |
申请公布号 |
EP3027753(A1) |
申请公布日期 |
2016.06.08 |
申请号 |
EP20140744565 |
申请日期 |
2014.07.29 |
申请人 |
UNIVERSITÄT ZU KÖLN |
发明人 |
WIRTH, BRUNHILDE;RIESSLAND, MARKUS |
分类号 |
C12N15/113;A61K31/7088;A61P25/00 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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