发明名称 |
SUBSTRATE RECOGNITION BY DIFFERENTIABLE HUMAN MESENCHYMAL STEM CELLS |
摘要 |
The invention described herein provides a structure for growing isolated differentiable human mesenchymal cells, which includes a three-dimensional matrix of fibers. The matrix serves as an implantable scaffolding for delivery of differentiable human mesenchymal cells in tissue engineering. The invention further provides compositions that contain the three-dimensional matrix of fibers seeded with isolated differentiable human mesenchymal cells, wherein the matrix forms a supporting scaffold for growing the isolated differentiable human mesenchymal cells, and wherein the differentiable human mesenchymal cells differentiate into a mature cell phenotype. The invention further provides methods of preparing the implantable nanofiber matrix scaffolding seeded with differentiable human mesenchymal cells for use in tissue engineering. |
申请公布号 |
EP1851858(B1) |
申请公布日期 |
2016.06.08 |
申请号 |
EP20050852938 |
申请日期 |
2005.12.01 |
申请人 |
NEW JERSEY INSTITUTE OF TECHNOLOGY |
发明人 |
ARINZEH, TREENA;JAFFE, MICHAEL;SHANMUGASUNDARAM, SHOBANA |
分类号 |
C12N5/077;A61K35/12;A61L27/18;A61L27/36;A61L27/38;A61L27/56;C12M1/12;C12N5/0775;D01D5/00;H03L7/093 |
主分类号 |
C12N5/077 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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