发明名称 |
THERAPEUTIC COMPOUNDS AND COMPOSITIONS |
摘要 |
Provided are aryl sulfonamide diarylurea derivative compounds that are inhibitors of mutant isocitrate dehydrogenase 1/2 (IDH 1/2), useful for treating cancer. Also provided are methods of treating cancer comprising administering to a subject in need thereof a compound described herein. Cancers that are treatable by the compounds of the invention are glioblastoma, myelodysplastic syndrome, myeloproliferative neoplasm, acute myelogenous leukemia, sarcoma, melanoma, non-small cell lung cancer, chondrosarcoma, and non-Hodgkin's lymphoma (NHL). |
申请公布号 |
EP2906212(A4) |
申请公布日期 |
2016.06.08 |
申请号 |
EP20130846787 |
申请日期 |
2013.10.11 |
申请人 |
AGIOS PHARMACEUTICALS, INC. |
发明人 |
POPOVICI-MULLER, JANETA;SALITURO, FRANCESCO GERALD;SAUNDERS, JEFFREY OWEN;TRAVINS, JEREMY;YAN, SHUNQI |
分类号 |
A61K31/17;A61K31/18;C07C311/44;C07D213/74;C07D239/42;C07D309/14;C07D333/20;C07D409/12;C07D413/12 |
主分类号 |
A61K31/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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