HYDRONAPHTHOQUINOLINE DERIVATIVE

摘要

The present invention provides a compound represented by general formula (I) which has excellent retinoic acid receptor-related orphan receptor γt inhibitory activity and IL-17 production inhibitory activity, or a pharmaceutically acceptable salt thereof. (In the formula, U represents a phenyl group, pyridyl group, tetrahydrofuryl group, tetrahydropyranyl group or benzyl group which may be independently mono- to tetra-substituted by groups selected from among halogen atoms, C1-C6 alkyl groups and C1-C6 alkoxy groups, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group or the like; R1 represents a hydrogen atom, a halogen atom, a hydroxyl group or the like; R2 represents a hydrogen atom or a C1-C6 alkyl group; R3 represents a hydrogen atom, a halogen atom, a hydroxyl group or the like; R4 represents a hydrogen atom or the like; R5 represents a C1-C6 alkyl group which may be independently mono- to tetra-substituted by groups selected from among a hydroxyl group and C1-C6 alkoxy groups, a hydrogen atom or the like; R6 represents a C1-C6 alkyl group which may be independently mono- or di-substituted by groups selected from among C1-C6 alkylsulfonyl groups and a hydroxyl group, a hydrogen atom, a hydroxyl group or the like; R7 represents a hydrogen atom or a fluorine atom; R8 represents a hydrogen atom, a fluorine atom or the like; R9 represents a hydrogen atom; T represents a single bond, an oxygen atom or a group represented by formula -NH-; Y may be the same or different and each represents a halogen atom or a C1-C6 alkyl group; m represents an integer of 0-3; a saturated ring containing a nitrogen atom may be fused with a cyclopropane ring to form a fused ring; and n represents an integer of 1-3.)