发明名称 ANNELATED PYRROLES AND THEIR USE AS CRAC INHIBITORS
摘要 The invention relates to substituted bicyclic pyrroloheterocyclyl compounds useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.
申请公布号 US2016151337(A1) 申请公布日期 2016.06.02
申请号 US201615019238 申请日期 2016.02.09
申请人 Grünenthal GmbH 发明人 VOSS Felix;RITTER Stefanie;NORDHOFF Sonja;WACHTEN Sebastian;OBERBÖRSCH Stefan;KLESS Achim
分类号 A61K31/437;A61K31/444;A61K31/5377;A61K31/497;A61K31/506;A61K31/501;C07D471/04;A61K31/635 主分类号 A61K31/437
代理机构 代理人
主权项 1. A compound of formula (I), wherein A1 and A2 represent direct bond or C(═O), with the proviso that 0 or 1 of A1 and A2 represents C(═O); m and n independently denote 0, 1, 2 or 3, with the proviso that the sum [n+m] is 1, 2, 3 or 4; R1 denotes H, F, Cl, Br, I, CN, CF3, CF2H, CFH2, CO2H, CO2R13, R13, OH, O—R13, NH2, N(H)R13, or N(R13)2; R2 represents 0 to 4 substituents, each independently selected from the group consisting of F, Cl, Br, CN, CF3, CF2H, CFH2, R13, OH, O—R13, NH2, N(H)R13 and N(R13)2; Ar1 represents phenyl or 5- or 6-membered heteroaryl, in each case unsubstituted or substituted with one, two, three or four substituents, independently selected from the group consisting of F, Cl, Br, CN, CF3, CF2H, CFH2, R13 and O—R13; orC3-6-cycloalkyl or 3 to 7 membered heterocycloalkyl, in each case unsubstituted or mono- or polysubstituted;Ar2 represents phenyl or 5- or 6-membered heteroaryl, wherein said phenyl or said heteroaryl is unsubstituted or mono- or polysubstituted and may be condensed with a 4-, 5-, 6- or 7-membered ring, being carbocyclic or heterocyclic, wherein said condensed ring may be saturated, partially unsaturated or aromatic and is unsubstituted or mono- or polysubstituted;andeach R13 independently of each other denotes C1-8-alkyl, unsubstituted or mono- or polysubstituted; orC3-6-cycloalkyl or 3 to 7 membered heterocycloalkyl, in each case unsubstituted or mono- or polysubstituted; orC3-6-cycloalkyl or 3 to 7 membered heterocycloalkyl, in each case unsubstituted or mono- or polysubstituted, and in each case connected via a C1-4-aliphatic group, unsubstituted or mono- or polysubstituted;in the form of the free compound or a physiologically acceptable salt thereof or a physiologically acceptable solvate thereof.
地址 Aachen DE
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