| 主权项 |
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from C1-C3alkoxy, C1-C3alkyl, cyano, diC1-C3alkylamino, halo, haloC1-C3alkoxy, haloC1-C3alkyl, hydroxy, and thienyl;R2 is selected from wherein Ra is selected from hydrogen, C1-C3alkoxy, C1-C3alkylamino, C1-C3alkylcarbonylamino, amino, and halo;R3 is selected from hydrogen and C1-C3alkyl;X is selected from hydrogen, C1-C3alkoxy, C1-C3alkyl, cyano, halo, haloC1-C3alkyl, Y is selected from hydrogen and halo;Z is selected from whereinn is 1 or 2;R4 is selected from C2-C6alkyl, C3-C6cycloalkyl, (C3-C6cycloalkyl)C1-C3alkyl, C1-3alkylthioC1-3alkyl, hydroxyC1-C6alkyl, and haloC1-C6alkyl;R5 and R6 are independently selected from hydrogen, C1-C3alkyl, C1-C3alkylsulfonyl, C3-C6cycloalkyl optionally substituted with an amino group, heterocyclyl, heterocyclylC1-C3alkyl, phenylC1-C3alkyl, phenylC1-C3alkylsulfonyl, and phenylsulfonyl; wherein the heterocyclyl, the heterocyclyl part of the heterocyclylC1-C3alkyl, and the phenyl part of the phenylC1-C3alkyl, phenylC1-C3alkylsulfonyl, and the phenylsulfonyl are optionally substituted with one group selected from C1-C3alkyl, halo, hydroxy; orR5 and R6, together with the nitrogen atom to which they are attached, form a five- or six-membered heterocyclic ring optionally containing a second nitrogen atom and optionally substituted with an amino group;Rb is selected from hydrogen, C1-C3alkoxy, C1-C3alkyl, halo, and halo C1alkyl;Rp is selected from hydrogen and C1-C3alkyl;Rq is selected from hydrogen and oxo; andRz is selected from hydrogen, C1-C3alkyl, and C1-C3alkylcarbonyl; or a pharmaceutically acceptable salt thereof. |
