| 主权项 |
1. A compound according to Formula (I): wherein a and b are independently 0, 1, or 2; c is 0, 1, 2, 3, or 4; R1 is hydrogen, C1-C6 alkyl, C2-C9 heteroaryl, C3-C10 carbocyclyl C1-C6 alkyl, C6-C10 aryl C1-C6 alkyl, C2-C9 heteroaryl C1-C6 alkyl, —C(O)NR7R8, —C(O)OR9, —C(O)R10, or —S(O)2R11; each R2 is independently hydroxyl, halogen, or —OR12; R3 is hydrogen or C1-C6 alkyl; R4 is hydrogen or C1-C6 alkyl; R5 is C1-C6 alkyl, or —(CH2)nX1R13, or R5 and R6 together with the carbon and nitrogen atoms to which they are respectively attached, combine to form a 5-8-membered heterocycle; R6 is hydrogen, C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C10 carbocyclyl C1-C6 alkyl, C6-C10 aryl C1-C6 alkyl, C2-C9 heteroaryl C1-C6 alkyl, C2-C9 heterocyclyl C1-C6 alkyl, N-protecting group, —C(O)R15, —C(O)NR16R17, or —S(O)2R18; R7 is hydrogen or C1-C6 alkyl; R8 is C6-C10 aryl, C2-C9 heteroaryl, C2-C9 heterocyclyl, or C3-C10 carbocyclyl; R9 is C1-C6 alkyl or C6-C10 aryl; R10 is C1-C6 alkyl, C6-C10 aryl, C2-C9 heterocyclyl, C6-C10 aryl C1-C6 alkyl, or C2-C9 heteroaryl C1-C6 alkyl; R11 is C1-C6 alkyl, C6-C10 aryl, or C6-C10 aryl C1-C6 alkyl; each R12 is C1-C6 alkyl or C1-C6 acyl; n is 1, 2, 3, 4, 5, or 6; X1 is absent, 0, or NR14; R13 is hydrogen, C1-C6 alkyl, C1-C6 heteroalkyl, C1-C6 perfluoroalkyl, C1-C6 acyl, C6-C10 aryl C1-C6 alkyl, an O- or N-protecting group, or R13 and R14 combine to form a 5-8-membered heterocycle; R14 is hydrogen or C1-C6 alkyl; R15 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C1-C6 heteroalkyl, C3-C10 carbocyclyl, C2-C9 heterocyclyl, C6-C10 aryl, C6-C10 aryl C1-C6 alkyl; R16 and R17 are independently hydrogen, C1-C6 alkyl, or C6-C10 aryl; and R18 is C1-C6 alkyl, C1-C6 perfluoroalkyl, C3-C10 carbocyclyl, or C6-C10 aryl; wherein the compound is not compound 12, compound 15, or any one of compounds 78-135 of Table 1, or a pharmaceutically acceptable salt thereof. |
