发明名称 |
DERIVATION OF NUERAL CREST STEM CELLS AND USES THEREOF |
摘要 |
The present invention is based in part the discovery of methods for the generation of neural crest stem cells (NCSCs) from human pluripotent stem cells (hPSCs). Specifically, the present invention discloses methods for the use of a combination of rho-associated protein kinase (ROCK) inhibitors, glycogen synthase kinase 3 (GSK-3) inhibitors, activing receptor like kinase (ALK) receptor inhibitors and bone morphogenic protein (BMP) receptor inhibitors to derive NCSCs from hPSCs. The present invention also discloses methods to treat neurocristopathic diseases and disorders using NCSCs derived from hPSCs. |
申请公布号 |
WO2016086052(A1) |
申请公布日期 |
2016.06.02 |
申请号 |
WO2015US62519 |
申请日期 |
2015.11.24 |
申请人 |
INTERNATIONAL STEM CELL CORPORATION |
发明人 |
SEMECKHKIN, RUSLAN;GONZALEZ, RODOLFO |
分类号 |
C12N5/071;A01N63/00;C12N5/00 |
主分类号 |
C12N5/071 |
代理机构 |
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