| 发明名称 |
LOW VISCOSITY COMPOSITIONS COMPRISING A PEGYLATED GLA-DOMAIN CONTAINING PROTEIN |
| 摘要 |
The present invention relates to a method for lowering the viscosity of compositions comprising Vitamin K-dependent proteins. |
| 申请公布号 |
US2016151464(A1) |
申请公布日期 |
2016.06.02 |
| 申请号 |
US201615015630 |
申请日期 |
2016.02.04 |
| 申请人 |
Novo Nordisk Healthcare AG |
发明人 |
Nielsen Anders Dybdal;Oestergaard Tina |
| 分类号 |
A61K38/48;A61K47/02 |
主分类号 |
A61K38/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising a Vitamin K-dependent protein of interest in a concentration of at least 25 mg/ml, said Vitamin K-dependent protein of interest being functionalised with one or more polyethylene glycol (PEG) moieties, said composition comprising a divalent metal cation in a concentration higher than 10 mM, wherein the viscosity is lower than 30 mPascal×second (mPa·s) as measured in a “Rheometer Viscosity Assay”. |
| 地址 |
Zurich CH |
