发明名称 RECOMBINANT HCMV AND RHCMV VECTORS AND USES THEREOF
摘要 Described herein are recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens. The recombinant vectors elicit and maintain high level cellular and humoral immune responses specific for the heterologous antigen. The recombinant RhCMV and HCMV vectors may be used, for example, for the treatment or prevention of infectious disease or cancer. In some examples, the recombinant RhCMV or HCMV vectors may include deletions in genes encoding immunomodulatory proteins. In some examples, the recombinant RhCMV or HCMV vectors may be deficient or impaired in their ability to replicate within a cell, disseminate within the host or spread among hosts by including a deletion in one or more genes essential or augmenting for CMV replication, dissemination or spread.
申请公布号 AU2016201853(A1) 申请公布日期 2016.06.02
申请号 AU20160201853 申请日期 2016.03.23
申请人 OREGON HEALTH & SCIENCE UNIVERSITY 发明人 PICKER, LOUIS;NELSON, JAY A.;FRUEH, KLAUS;JARVIS, MICHAEL A.;HANSEN, SCOTT G.
分类号 C12N15/869;A61K39/12;A61P31/12;A61P35/00;C12N15/33 主分类号 C12N15/869
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