| 发明名称 |
OXAZOLIDINONE DERIVATIVES AS PPAR LIGANDS |
| 摘要 |
The present invention relates to a family of differently substituted oxazolidinones and to the pharmaceutically acceptable salts, esters, prodrugs, tautomers, solvates and hydrates thereof, which show affinity for the alpha and gamma subtypes of the peroxisome proliferator-activated receptors (PPAR) and which, therefore, modulate the actions regulated by said receptors, such as inducing satiety, controlling ingestion and modulating metabolic effects, and thus are useful for the administration thereof as a pharmacological tool and as drugs for the treatment and/or prevention of metabolic diseases and cardiovascular diseases. |
| 申请公布号 |
US2016152579(A1) |
申请公布日期 |
2016.06.02 |
| 申请号 |
US201414904228 |
申请日期 |
2014.07.11 |
| 申请人 |
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) ;SERVICIO ANDALUZ DE SALUD ;FUNDACIÓN PÚBLICA ANDALUZA PARA LA INVESTIGACIÓN DE MÁLAGA EN BIOMEDICINA Y SALUD (FIMABIS) |
发明人 |
Pérez Fernández Ruth;Fresno López María Nieves;Elguero Bertolini José;Goya Laza Pilar;Torres Zaguirre Ana Belén;Rodíguez De Fonseca Fernando;Pavón Morón Francisco Javier;Macías González Manuel;Romero Cuevas Miguel |
| 分类号 |
C07D263/22;A61K8/49;A61K31/421 |
主分类号 |
C07D263/22 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A compound of general formula (I)or any of the pharmaceutically acceptable salts, esters, tautomers, solvates and hydrates thereof, where:
R1 is selected from (C1-C12) alkyl, cycloalkyl or —(CH2)—R3 where R3 is cycloalkyl or aryl; R2 is selected from (C1-C12) alkyl, aralkyl, aryl and amino. |
| 地址 |
Madrid ES |
