发明名称 |
METHOD FOR PROVIDING VASCULAR SYSTEM IN BIOLOGICAL TISSUE |
摘要 |
The present invention provides a method of constituting a tissue construct in vitro using a tissue without depending on scaffold materials. A method of integrating a biological tissue with a vascular system in vitro, comprising coculturing a biological tissue with vascular cells and mesenchymal cells. A biological tissue which has been integrated with a vascular system by the above-described method. A method of preparing a tissue or an organ, comprising transplanting the biological tissue described above into a non-human animal and differentiating the biological tissue into a tissue or an organ in which vascular networks have been constructed. A method of regeneration or function recovery of a tissue or an organ, comprising transplanting the biological tissue described above into a human or a non-human animal and differentiating the biological tissue into a tissue or an organ in which vascular networks have been constructed. A method of preparing a non-human chimeric animal, comprising transplanting the biological tissue described above into a non-human animal and differentiating the biological tissue into a tissue or organ in which vascular networks have been constructed. A method of evaluating a drug, comprising using at least one member selected from the group consisting of the biological tissue described above, the tissue or organ prepared by the method described above, and the non-human chimeric animal prepared by the method described above. A composition for regenerative medicine, comprising a biological tissue which has been integrated with a vascular system by the method described above. |
申请公布号 |
EP3026110(A1) |
申请公布日期 |
2016.06.01 |
申请号 |
EP20140829625 |
申请日期 |
2014.07.15 |
申请人 |
PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY |
发明人 |
TAKEBE, Takanori;TANIGUCHI, Hideki;TAKAHASHI, Yoshinobu |
分类号 |
C12N5/071;A01K67/027;A61L27/00;C07D499/21;G01N33/50 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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