POST-SYNTHETIC ORTHOGONAL AMIDATION PLUS METAL CATALYZED AZIDE-ALKYNE CYCLOADDITION CLICK CHEMISTRY ON siRNA
摘要
This invention relates to the post-synthetic chemical modifications of RNA at the 2′-position on the ribose rings via orthogonal chemistry involving amidation reactions plus metal catalyzed alkyne-azide cycloaddition (click) reactions.
申请公布号
EP2934551(A4)
申请公布日期
2016.06.01
申请号
EP20130865727
申请日期
2013.12.18
申请人
SIRNA THERAPEUTICS, INC.
发明人
ZEWGE, DANIEL;COPELAND, GREGORY, T.;LI, ZHEN;ARMSTRONG, JOSEPH, D., III
