Multicyclic compounds and methods of use thereof

摘要

Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. For example, disclosed herein are compounds having formula (IIa) shown below, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the variables are defined herein. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.;

主权项

1. A compound of formula (IIa):or a pharmaceutically acceptable salt or stereoisomer thereof, wherein
(i) R1 and R3 together with the atoms to which they are attached form 5-membered heterocyclyl, and R4 is hydrogen or C1-C6 alkyl; or (ii) R3 and R4 together form a double bond and together with R1 and the atoms to which they are attached form a 5-membered heteroaryl; R2 is hydrogen or C1-C6 alkyl; R5 is hydrogen or C1-C6 alkyl; R6 and R7 are each independently (i) hydrogen, halo, C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 aminoalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl C1-C6 alkyl, 6- to 10-membered aryl, or 6- to 10-membered C1-C6 aralkyl; or (ii) —(CH2)p—R11, wherein R11 is CF3, CN, nitro, amino, hydroxyl, C3-C7 cycloalkoxyl, 5- to 10-membered heteroaryl, or 3- to 8-membered heterocyclyl; m is 0, 1, or 2; n is 0, 1, or 2; and each occurrence of p is independently 0, 1, or 2.