| 主权项 |
1. A compound of formula I or a pharmaceutically acceptable salt thereof, Wherein X is an alkyl, alkylamino, cycloalkyl, aryl, or heterocycle; Q is H, (CH2)qNR1R2, NR1(CH2)pNRbRc, OR1, SR1, or CHR1R2, in which q is 0 or 1 and p is 2-4; R1 and R2 are each independently hydrogen, alkyl, alkenyl, cycloalkyl, alkylcycloalkyl, aryl, alkylaryl, heterocycle, alkylheterocycle, or R1 and R2 together with the nitrogen atom to which they are bonded form a heterocycle, which may be optionally substituted by from one to four groups which may be the same or different selected from (C1-C4)alkyl, phenyl, benzyl, C(═O)R12, (CH2)pORa, and (CH2)pNRbRc, in which p is 2-4; R7 is heteroaryl or NR3R4, wherein the heteroaryl is optionally substituted by (C1-C4)alkyl; R3 and R4 are each independently hydrogen, alkyl, cycloalkyl, alkenyl, aryl or alkylaryl, or R3 and R4 together with the nitrogen atom to which they are bonded form a heterocycle; Y is NR11, where R11 is hydrogen, alkyl, cycloalkyl, alkenyl, or aryl group; R12 is alkyl, aryl, or heterocycle; L is alkyl or alkenyl containing from 2 to 10 carbon atoms; R5 is hydrogen, halogen, cyano, nitro, CF3, OCF3, alkyl, cycloalkyl, alkenyl, aryl, heterocycle, ORa, SRa, S(═O)Ra, S(═O)2Ra, NRbRc, S(═O)2NRbRc, C(═O)ORa, C(═O)Ra, C(═O)NRbRc, OC(═O)Ra, OC(═O)NRbRc, NRbC(═O)ORa, or NRbC(═O)Ra; R6 is (CH2)rC(═O)O(C1-C4)alkyl, aryl, heterocycle, (CH2)pNRbRc, or alkylheterocycle, wherein r is 0-4 and p is 2-4; each occurrence of Ra is independently hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, heterocycle, or aryl; and each occurrence of Rb, and Rc is independently hydrogen, alkyl, cycloalkyl, heterocycle, aryl, or said Rb and Rc together with the nitrogen atom to which they are bonded optionally form a heterocycle. |
