Process for preparing a crosslinked hyaluronic acid gel via homogenization in a deformable pouch

摘要

A process for preparing a crosslinked gel of at least one polymer or one of its salts, including a) providing an aqueous medium containing at least one polymer, b) forming a homogenous gel from the medium from step a), c) bringing the gel obtained in step b) into contact with an effective amount of at least one crosslinking agent; d) crosslinking the mixture formed in step c); and e) recovering the crosslinked hydrogel, wherein at least steps a) to d) are carried out within a hermetic cavity delimited at least partially by a deformable wall, the mixture present in the cavity being exposed, in step d), to conditions conducive to crosslinking.

主权项

1. A process for preparing a crosslinked gel of hyaluronic acid or one of its salts, comprising at least the steps of:
a) providing an aqueous medium containing said hyaluronic acid or one of its salts; b) forming a homogeneous gel from the medium from step a), wherein the homogenization takes place over a duration ranging from 30 to less than 150 minutes; c) bringing the gel obtained in step b) into contact with an effective amount of butanediol diglyceryl ether, forming a mixture; d) crosslinking said mixture formed in step c), forming a crosslinked hydrogel; and e) recovering said the crosslinked hydrogel;
wherein at least said steps a) to d) are carried out within a hermetic deformable pouch.