Compounds, Methods, and Treatments for Abnormal Signaling Pathways for Prenatal and Postnatal Development

摘要

The present invention relates to prevention of congenital deformations. The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events and gene expression during prenatal development, post-natal development, and during development in the adult organism. The invention also relates to activators or deactivators of pyruvate kinase M2 (PKM2) for the treatment, prevention, or amelioration of diseases related to PKM2 function.

主权项

1. A compound effective for moderating the activity of PKM2 via signaling cascades, to regulate metabolic pathways in rapidly growing tissues related to disease states such as cancer, obesity, and diabetes including any D-Chiro inositol as listed herein, their isomeric analogous phosphate derivatives, and/or their isomeric analogous phosphatidyl inositol phosphate derivatives comprising:
at least one compound selected from the group consisting of D-chiro-inositol 1,2,3,4-tetraphosphate, D-chiro-inositol 1,2,3,5-tetraphosphate, D-chiro-inositol 1,2,3,6-tetraphosphate, D-chiro-inositol 1,2,4,5-tetraphosphate, D-chiro-inositol 1,2,4,6-tetraphosphate, D-chiro-inositol 1,3,4,5-tetraphosphate, D-chiro-inositol 1,3,4,6-tetraphosphate, D-chiro-inositol 1,3,5,6-tetraphosphate, D-chiro-inositol 1,4,5,6-tetraphosphate, D-chiro-inositol 2,3,4,5-tetraphosphate, D-chiro-inositol 2,3,4,6-tetraphosphate, D-chiro-inositol 2,3,5,6-tetraphosphate, D-chiro-inositol 2,4,5,6-tetraphosphate, D-chiro-inositol 3,4,5,6-tetraphosphate, D-chiro-inositol 1,2,3,4,5-pentaphosphate, D-chiro-inositol 1,2,3,4,6-pentaphosphate, D-chiro-inositol 1,2,3,5,6-pentaphosphate, D-chiro-inositol 1,2,4,5,6-pentaphosphate, D-chiro-inositol 1,3,4,5,6-pentaphosphate, D-chiro-inositol 2,3,4,5,6-pentaphosphate, D-chiro-inositol 1,2,3,4,5,6-hexaphosphate, D-chiro-inositol 1,2,3,4,5-pentaphosphate-6-pyrophosphate, D-chiro-inositol 1,2,3,4,6-pentaphosphate-5-pyrophosphate, D-chiro-inositol 1,2,3,5,6-pentaphosphate-4-pyrophosphate, D-chiro-inositol 1,2,4,5,6-pentaphosphate-3-pyrophosphate, D-chiro-inositol 1,3,4,5,6-pentaphosphate-2-pyrophosphate, D-chiro-inositol 2,3,4,5,6-pentaphosphate-1-pyrophosphate, D-chiro-inositol 1,2,3-triphosphate-4,5-dipyrophosphate, D-chiro-inositol 1,2,3-triphosphate-4,6-dipyrophosphate, D-chiro-inositol 1,2,3-triphosphate-5,6-dipyrophosphate, D-chiro-inositol 1,2,4-triphosphate-3,5-dipyrophosphate, D-chiro-inositol 1,2,4-triphosphate-3,6-dipyrophosphate, D-chiro-inositol 1,2,4-triphosphate-5,6-dipyrophosphate, D-chiro-inositol 1,2,5-triphosphate-3,4-dipyrophosphate, D-chiro-inositol 1,2,5-triphosphate-3,6-dipyrophosphate, D-chiro-inositol 1,2,5-triphosphate-4,6-dipyrophosphate, D-chiro-inositol 1,2,6-triphosphate-3,4-dipyrophosphate, D-chiro-inositol 1,2,6-triphosphate-3,5-dipyrophosphate, D-chiro-inositol 1,2,6-triphosphate-4,6-dipyrophosphate, D-chiro-inositol 1,3,4-triphosphate-2,5-dipyrophosphate, D-chiro-inositol 1,3,4-triphosphate-2,6-dipyrophosphate, D-chiro-inositol 1,3,4-triphosphate-5,6-dipyrophosphate, D-chiro-inositol 1,3,5-triphosphate-2,4-dipyrophosphate, D-chiro-inositol 1,3,5-triphosphate-2,6-dipyrophosphate, D-chiro-inositol 1,3,5-triphosphate-4,6-dipyrophosphate, D-chiro-inositol 1,3,6-triphosphate-2,4-dipyrophosphate, D-chiro-inositol 1,3,6-triphosphate-2,5-dipyrophosphate, D-chiro-inositol 1,3,6-triphosphate-4,5-dipyrophosphate, D-chiro-inositol 1,4,5-triphosphate-2,3-dipyrophosphate, D-chiro-inositol 1,4,5-triphosphate-2,6-dipyrophosphate, D-chiro-inositol 1,4,5-triphosphate-3,6-dipyrophosphate, D-chiro-inositol 1,4,6-triphosphate-2,3-dipyrophosphate, D-chiro-inositol 1,4,6-triphosphate-2,5-dipyrophosphate, D-chiro-inositol 1,4,6-triphosphate-3,5-dipyrophosphate, D-chiro-inositol 1,5,6-triphosphate-2,3-dipyrophosphate, D-chiro-inositol 1,5,6-triphosphate-2,4-dipyrophosphate, D-chiro-inositol 1,5,6-triphosphate-3,4-dipyrophosphate, D-chiro-inositol 2,3,4-triphosphate-1,5-dipyrophosphate, D-chiro-inositol 2,3,4-triphosphate-1,6-dipyrophosphate, D-chiro-inositol 2,3,4-triphosphate-5,6-dipyrophosphate, D-chiro-inositol 2,3,5-triphosphate-1,4-dipyrophosphate, D-chiro-inositol 2,3,5-triphosphate-1,6-dipyrophosphate, D-chiro-inositol 2,3,5-triphosphate-4,6-dipyrophosphate, D-chiro-inositol 2,3,6-triphosphate-1,4-dipyrophosphate, D-chiro-inositol 2,3,6-triphosphate-1,5-dipyrophosphate, D-chiro-inositol 2,3,6-triphosphate-4,5-dipyrophosphate, D-chiro-inositol 2,4,5-triphosphate-1,3-dipyrophosphate, D-chiro-inositol 2,4,5-triphosphate-1,6-dipyrophosphate, D-chiro-inositol 2,4,5-triphosphate-3,6-dipyrophosphate, D-chiro-inositol 2,4,6-triphosphate-1,3-dipyrophosphate, D-chiro-inositol 2,4,6-triphosphate-1,5-dipyrophosphate, D-chiro-inositol 2,4,6-triphosphate-3,5-dipyrophosphate, D-chiro-inositol 2,5,6-triphosphate-1,3-dipyrophosphate, D-chiro-inositol 2,5,6-triphosphate-1,4-dipyrophosphate, D-chiro-inositol 2,5,6-triphosphate-3,4-dipyrophosphate, D-chiro-inositol 3,4,5-triphosphate-1,2-dipyrophosphate, D-chiro-inositol 3,4,5-triphosphate-1,6-dipyrophosphate, D-chiro-inositol 3,4,5-triphosphate-2,6-dipyrophosphate, D-chiro-inositol 3,5,6-triphosphate-1,2-dipyrophosphate, D-chiro-inositol 3,5,6-triphosphate-1,4-dipyrophosphate, D-chiro-inositol 3,5,6-triphosphate-2,4-dipyrophosphate, D-chiro-inositol 4,5,6-triphosphate-1,2-dipyrophosphate, D-chiro-inositol 4,5,6-triphosphate-1,3-dipyrophosphate, D-chiro-inositol 4,5,6-triphosphate-2,3-dipyrophosphate, D-chiro-inositol 1-phosphate-2,3,4-tripyrophosphate, D-chiro-inositol 1-phosphate-2,3,5-tripyrophosphate, D-chiro-inositol 1-phosphate-2,3,6-tripyrophosphate, D-chiro-inositol 1-phosphate-2,4,5-tripyrophosphate, D-chiro-inositol 1-phosphate-2,4,6-tripyrophosphate, D-chiro-inositol 1-phosphate-2,5,6-tripyrophosphate, D-chiro-inositol 1-phosphate-3,4,5-tripyrophosphate, D-chiro-inositol 1-phosphate-3,4,6-tripyrophosphate, D-chiro-inositol 1-phosphate-3,5,6-tripyrophosphate, D-chiro-inositol 1-phosphate-4,5,6-tripyrophosphate, D-chiro-inositol 2-phosphate-1,3,4-tripyrophosphate, D-chiro-inositol 2-phosphate-1,3,5-tripyrophosphate, D-chiro-inositol 2-phosphate-1,3,6-tripyrophosphate, D-chiro-inositol 2-phosphate-1,4,5-tripyrophosphate, D-chiro-inositol 2-phosphate-1,4,6-tripyrophosphate, D-chiro-inositol 2-phosphate-1,5,6-tripyrophosphate, D-chiro-inositol 2-phosphate-3,4,5-tripyrophosphate, D-chiro-inositol 2-phosphate-3,4,6-tripyrophosphate, D-chiro-inositol 2-phosphate-3,5,6-tripyrophosphate, D-chiro-inositol 2-phosphate-4,5,6-tripyrophosphate, D-chiro-inositol 3-phosphate-1,2,4-tripyrophosphate, D-chiro-inositol 3-phosphate-1,2,5-tripyrophosphate, D-chiro-inositol 3-phosphate-1,2,6-tripyrophosphate, D-chiro-inositol 3-phosphate-1,4,5-tripyrophosphate, D-chiro-inositol 3-phosphate-1,4,6-tripyrophosphate, D-chiro-inositol 3-phosphate-1,5,6-tripyrophosphate, D-chiro-inositol 3-phosphate-3,4,5-tripyrophosphate, D-chiro-inositol 3-phosphate-3,4,6-tripyrophosphate, D-chiro-inositol 3-phosphate-3,5,6-tripyrophosphate, D-chiro-inositol 3-phosphate-4,5,6-tripyrophosphate, D-1-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-1-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-1-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-1-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-1-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-2-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-2-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-2-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-2-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-2-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-3-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-3-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-3-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-3-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-3-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-4-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-4-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-4-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-4-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-4-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-5-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-5-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-5-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-5-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-5-deoxy-6-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-6-deoxy-1-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-6-deoxy-2-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-6-deoxy-3-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-6-deoxy-4-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], D-6-deoxy-5-O-methyl-D-chiroinositol-[1-(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate], 1D-6-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-6-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-6-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-6-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-6-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-5-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-5-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-5-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-5-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-5-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-4-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-4-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-4-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-4-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-4-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-3-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-3-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-3-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-3-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-3-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-2-hydroxymethyl-chiro-inositol-1-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-2-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-2-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-2-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-2-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-1-hydroxymethyl-chiro-inositol-2-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-1-hydroxymethyl-chiro-inositol-3-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-1-hydroxymethyl-chiro-inositol-4-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, 1D-1-hydroxymethyl-chiro-inositol-5-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate, and 1D-1-hydroxymethyl-chiro-inositol-6-(R)-2-methoxy-3-O-octadecyl-sn-glycerocarbonate.