| 发明名称 |
NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NgR) AND USES THEREOF |
| 摘要 |
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental. |
| 申请公布号 |
US2016145334(A1) |
申请公布日期 |
2016.05.26 |
| 申请号 |
US201614989532 |
申请日期 |
2016.01.06 |
| 申请人 |
AbbVie Deutschland GmbH & Co. KG ;AbbVie Inc. |
发明人 |
Mezler Mario;Moeller Achim;Mueller Reinhold;Mueller Bernhard K.;Ghayur Tariq;Barlow Eve H.;Schmidt Martin;Meyer Axel;Teusch Nicole |
| 分类号 |
C07K16/28;A61K39/395 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated binding protein that specifically interacts to at least one epitope of a Nogo-66 receptor. |
| 地址 |
Wiesbaden DE |
