The present relates to LNA gapmer antisense oligonucleotides which comprise stereodefined phosphoramidite linkages. The use of stereodefined phosphoramidite linkages in LNA gapmers has been found to provide enhanced RNaseH activity, and modifying stereospecificity enables the reduced toxicity, altered biodistribution, and enhanced mismatch discrimination.
申请公布号
WO2016079181(A1)
申请公布日期
2016.05.26
申请号
WO2015EP76967
申请日期
2015.11.18
申请人
ROCHE INNOVATION CENTER COPENHAGEN A/S
发明人
ALBÆK, NANNA;HANSEN, HENRIK FRYDENLUND;KOCH, TROELS;RAVN, JACOB;ROSENBOHM, CHRISTOPH;HAGEDORN, PETER;SEWING, SABINE;MOISAN, ANNIE