ANTI-CANCER COMPOUNDS

摘要

Provided are methods and compositions for the treatment of diseases such as cancer. In certain aspects, compounds which can inhibit Skp2 are provided. Specifically chromenone derivatives are disclosed that have the capability toward reducing differentiation of pluripotent, multipotent or totipotent cells and thus have therapeutic utility in the treatment of a proliferative disease such as cancer.

主权项

1. A method of treating a hyperproliferative disease, comprising administering to a subject an effective amount of a compound having the structure: wherein R1 is heteroaryl(C≦18) or substituted heteroaryl(C≦18); R2, R3, R4, R5, R7, R8, R9, and R10 are each independently selected from the group consisting of hydrogen, alkyl(C≦18), substituted alkyl(C≦18); heteroaryl(C≦18), substituted heteroaryl(C≦18), heterocycloalkyl(C≦18), substituted heterocycloalkyl(C≦18), acyl(C≦18), C(O)O-alkyl(C≦18), -alkyl(C≦12)-heterocycloalkyl(C≦18), aryl(C≦18), OH, —SH, CF3, X1 and X2 are each independently hydrogen, substituted alkyl(C1-12), or alkyl(C1-12); X3 is alkyl(C≦12) or substituted alkyl(C≦12); Y1 is —H, aryl(C≦18), or heteroaryl(C≦18); and R6 is selected from the group consisting of —H, alkyl(C≦18), —NH2, C(O)Oalkyl(C≦18), and substituted alkyl(C≦18); R11 is -alkyl(C≦6)-heterocycloalkyl(C≦18) or -alkyl(C≦6)-substituted heterocycloalkyl(C≦18); or a pharmaceutically acceptable salt or tautomer thereof.