主权项 |
1. A pharmaceutical composition comprising a first portion comprising a first subtherapeutic amount of aspirin, and a second portion comprising a second subtherapeutic amount of aspirin, wherein, upon oral administration to a subject, the first portion disintegrates or dissolves intraorally providing rapid release of the aspirin of the first portion, and the second portion is substantially more difficult than the first portion to disintegrate or dissolve intraorally but is ingestible and releasable in the gastrointestinal track of the subject. |